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apalutamide will minimize the level or outcome of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP2C19 inducer, with medications which are CYP2C19 substrates can lead to decreased publicity to these medicines.Outcome of coadministration of the twin CYP3A4 and CYP2C